Anthony Ramos

Beginning in 2011, Ramos earned roles in a variety of regional and touring musical productions, including Usnavi de la Vega in a 2012 production of In the Heights. In 2014, he performed in Heart and Lights at Radio City Music Hall, a dance show with the Rockettes which was canceled during previews. During rehearsals for Heart and Lights, Ramos auditioned for the off-Broadway production of Hamilton at The Public Theater. After being cast in Hamilton, Ramos played Justin Laboy in Lin-Manuel Miranda's short musical 21 Chump Street, a 14-minute, one-time performance on June 7, 2014, which was recorded for This American Life.

Hamilton opened off-Broadway in early 2015, with Ramos originating the dual role of John Laurens and Philip Hamilton, the oldest son of Alexander Hamilton. The musical moved to Broadway on July 13, 2015, in previews, and opened on August 6, 2015. Ramos left the production on November 20, 2016, being replaced by Jordan Fisher.

In September 2016, it was announced that Ramos had been cast in director Spike Lee's Netflix comedy-drama series She's Gotta Have It, in the role of Mars Blackmon. Ramos played the role of Ramon in the 2018 remake of A Star Is Born, starring Lady Gaga and Bradley Cooper, and directed by Cooper. In 2018, Variety reported that Ramos had been cast as Usnavi de la Vega in the film adaptation of In the Heights. The movie was released in 2021 to significant acclaim, but was a box-office bomb. In April 2021, Ramos was cast in the lead role in the next installment of the Transformers film franchise, Transformers: Rise of the Beasts. The film was released on June 9, 2023.

In February 2022, Ramos was cast as Parker Robbins / The Hood in the upcoming superhero streaming series Ironheart, set in the Marvel Cinematic Universe. In January 2024, Ramos was cast as the lead voice role in a Bob the Builder animated film. In July 2024, Ramos appeared in Twisters, the sequel to the 1996 film Twister.