Fahy had her first prominent role playing Hannah O'Connor on the ABC daytime soap opera One Life to Live (2010–2012) and made her Broadway debut in the musical Next to Normal (2010–2011). After her first two film roles in the 2015 dramas Those People and Burning Bodhi, Fahy had her breakthrough with a starring role in the Freeform drama series The Bold Type (2017–2021).
In 2022, Fahy received critical acclaim for her starring role in the second season of the HBO anthology series The White Lotus, for which she was nominated for Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series. She has since starred in the Netflix mystery series The Perfect Couple (2024), the thriller film Drop (2025), and the limited series Sirens (2025), lattermost for which she nominated for Primetime Emmy Award Outstanding Lead Actress in a Limited or Anthology Series or Movie.
Fahy was cast as the standby for Jennifer Damiano as Natalie Goodman in Arena Stage's production of Next to Normal in late 2008. She remained with the cast during its transfer to the Booth Theatre on Broadway, which began previews on March 27, 2009. On July 19, 2010, Fahy took over as the principal actor for Natalie. Fahy played the role on Broadway until its closing on January 16, 2011.
In May 2011, Fahy briefly reprised her role as Natalie Goodman in the first national tour of Next to Normal in the first week of the St. Paul, Minnesota stop. In July 2011, it was announced that Fahy had been cast in The Unauthorized Autobiography of Samantha Brown at Goodspeed Opera House. She reprised her role as the title character when performances began August 4, 2011, and continued through August 28, 2011.
In January 2012, Fahy appeared in a one-night concert reading of Twilight: The Musical at New World Stages as Bella. In January 2015, Fahy participated in a production of We Are The Tigers at Feinstein's/54 Below, singing as Riley Williams.
In fall 2015, Fahy starred Off-Broadway in Lost Girls at MCC Theater playing the role Penny.
In winter 2017, Fahy starred in Penelope Skinner's play Linda at Manhattan Theatre Club Off-Broadway, playing a rock singer.
Meghann Fahy has appeared on Broadway in 1 shows.
Meghann Fahy has not appeared in the West End.
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