Born to a British mother and a Swedish father, Ferguson began her television acting career in 1999 with the Swedish soap opera Nya tider and made her motion picture acting debut in 2004 with the Swedish slasher film Drowning Ghost. She came to international prominence with her portrayal of Elizabeth Woodville in the British drama The White Queen (2013), for which she was nominated for a Golden Globe for Best Actress in a Miniseries or Television Film.
In American cinema, Ferguson portrayed MI6 agent Ilsa Faust, opposite Tom Cruise, in three of the Mission: Impossible films: Rogue Nation (2015), Fallout (2018), and Dead Reckoning (2023) and Lady Jessica in the science fiction films Dune (2021) and Dune: Part Two (2024). She played Jenny Lind in the musical film The Greatest Showman (2017), and acted in the horror films Life (2017) and Doctor Sleep (2019), the comedy-drama Florence Foster Jenkins (2016), thriller The Girl on the Train (2016), and the political drama A House of Dynamite (2025).
Since 2023, she has starred in the Apple TV+ science fiction series Silo playing an intelligent engineer in an underground community, a role for which she has received nominations for a Saturn Award and a Satellite Award.
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