Drescher made her screen debut in the 1977 blockbuster film Saturday Night Fever, and later appeared in American Hot Wax (1978) and Wes Craven's horror tale Stranger in Our House (1978). In the 1980s, she gained recognition in the films Gorp (1980), The Hollywood Knights (1980), Doctor Detroit (1983), This Is Spinal Tap (1984), and UHF (1989). She also established a television career with guest appearances on several series. In 1993, she achieved wider fame as Fran Fine in her own sitcom The Nanny, for which she was nominated for two Emmy Awards and two Golden Globe Awards for Best Actress in a Comedy Television Series. She received further recognition for her performances in Jack (1996) and The Beautician and the Beast (1997) and reinforced her position as a leading sitcom star with Living with Fran (2005–2006) and along with the cult classic Santa's Slay (2005)Happily Divorced (2011–2013).