James Spader

Spader's first major film role was in the film Endless Love (1981), and his first starring role was in Tuff Turf (1985). He rose to stardom in 1986, when he played the rich, arrogant playboy Steff in Pretty in Pink. He co-starred in Mannequin (1987) and the film adaptation of Less than Zero (1987), in which he played a drug dealer named Rip. Supporting roles in films such as Baby Boom (1987) and Wall Street (1987) followed until his breakthrough in Sex, Lies, and Videotape (1989), in which he played a sexual voyeur who complicates the lives of three Baton Rouge, Louisiana residents. For this performance he received the Best Actor Award at the Cannes Film Festival.

Spader's roles in the early 1990s included a young, affluent widower opposite Susan Sarandon in the romantic drama White Palace (1990), a yuppie who meets the mysterious Rob Lowe in the Noir drama Bad Influence (1990), John Cusack's best friend in the drama True Colors (1991), and a poker-playing drifter in The Music of Chance (1993). In 1994, he starred as Egyptologist Daniel Jackson in the sci-fi film Stargate. In 1996, he played car accident fetishist James Ballard in the controversial Canadian film Crash and assassin Lee Woods in 2 Days in the Valley. In 1997, Spader guest starred in the Seinfeld episode "The Apology", as an angry recovering alcoholic who refuses to apologize to George for making fun of him. In 2000, he played a drug-addicted detective tracking a serial killer in The Watcher. In 2002, he starred as a sadomasochistic boss in Secretary.

From 2004 to 2008, Spader starred as Alan Shore in the series Boston Legal, in which he reprised his role from the television series The Practice (2003). Longtime writer-producer David E. Kelley said there was resistance when he first tried to cast Spader in the role, "I was told that no one would ever welcome James Spader into their living room". During a TV Game Changers interview Kelley noted, "People will watch him (Spader) in the movies, but they will never let him in their own home."

He won the Emmy Award for Outstanding Lead Actor in a Drama Series in 2004 for his portrayal on The Practice and won it again in 2005 and 2007 for Boston Legal. With the 2005 win, he became one of only a few actors to win an Emmy Award while playing the same character in two series. Even rarer, he won a second consecutive Emmy while playing the same character in two series. He also won the Satellite Award for Best Actor in a Series, Comedy or Musical for Boston Legal in 2006.

In October 2006, Spader narrated "China Revealed", the first episode of Discovery Channel's documentary series Discovery Atlas. He also did voice-over in several television commercials for Acura. He starred in Race, a play written and directed by David Mamet, which opened on December 6, 2009, at the Ethel Barrymore Theatre on Broadway. The show closed on August 21, 2010, after 297 performances. In March 2011, he was named to star in the film By Virtue Fall, written and to be directed by Sheldon Turner. As of June 2011, the movie was in pre-production.

Spader guest-starred as Robert California in "Search Committee", the season 7 finale of The Office. He then joined the cast as a regular member for the eighth season. While the original plan was just to do a guest appearance, executive producer Paul Lieberstein later said, "Those two scenes became a season".

Spader starred in the television series, The Blacklist, which premiered on NBC September 23, 2013, and which had its series finale on July 13, 2023, a total of ten seasons. He portrayed Raymond "Red" Reddington, one of the FBI's most wanted fugitives.

He also played the villainous robot Ultron in Avengers: Age of Ultron (2015), and will reprise the role in the upcoming Disney+ series VisionQuest (2026).