Kaley Cuoco

Kaley Cuoco began her acting career as a child, appearing in the television film Quicksand: No Escape (1992) as Connie Reinhardt. Her early television credits included My So-Called Life (1994), in which she played young Angela Chase, Northern Exposure (1994) as Miranda, and Ellen (1996) as Little Ellen Morgan. She appeared in the television films Toothless (1997) as Lori and Mr. Murder (1998) as Charlotte Stillwater, and played Pammie Green in an episode of The Tony Danza Show (1998). Her early film credits included Virtuosity (1995) as Karin Carter, Picture Perfect (1997) as Little Girl, and Can't Be Heaven (1999) as Teresa Powers. In 2000, she appeared in the television film Growing Up Brady as Maureen McCormick and the Disney Channel original film Alley Cats Strike as Elisa Bowers. She also appeared in an episode of Don't Forget Your Toothbrush (2000) as Ashley.

In 2001, Cuoco played Bonnie Stiles in the sitcom Ladies Man and appeared as Lynn in an episode of 7th Heaven. Her subsequent television credits included First Monday (2002) as Alyssa, The Ellen Show (2002) as Vanessa, and The Nightmare Room (2002) as Kristin Ferris. In September 2002, she began starring as Bridget Hennessy in the ABC sitcom 8 Simple Rules, appearing in the series through 2005. She also appeared as Carly Michaels in the pilot episode of The Help (2004), played Amanda Williams in the television miniseries 10.5 (2004), and appeared as herself in an episode of Punk'd (2004). Her other 2004 television credits included the television film Crimes of Fashion as Brooke Sarto, the television film The Hollow as Karen, and an episode of Complete Savages as Erin.

Cuoco voiced Brandy Harrington in the Disney Channel animated series Brandy & Mr. Whiskers from 2004 to 2006. She also voiced Kirstee Smith in the animated series Bratz from 2005 to 2006, reprising the role in the films Bratz Passion 4 Fashion – Diamondz (2006) and Bratz: Genie Magic (2006). From 2005 to 2007, she voiced Paula Hayes and Weather Vane in three episodes of Loonatics Unleashed. She played Billie Jenkins in the television series Charmed from 2005 to 2006. Her film credits during this period included Debating Robert Lee (2004) as Maralee Rodgers, Lucky 13 (2005) as Sarah Baker, and Wasted (2006) as Katie Cooning.

In 2007, Cuoco starred as Alyson Schmidt in the Lifetime television film To Be Fat Like Me and appeared as Sasha Murray in two episodes of Prison Break. That year, she began playing Penny in the CBS sitcom The Big Bang Theory, remaining a main cast member through the show's conclusion in 2019. Her film credits during the series included Cougar Club (2007) as Amanda, Killer Movie (2008) as Blanca Champion, The Penthouse (2010) as Erica Roc, Hop (2011) as Sam O'Hare, and The Last Ride (2011) as Wanda. She hosted the Teen Choice Awards in 2011 and the People's Choice Awards in 2012 and 2013. In 2012, she played Stacy Peterson in the television film Drew Peterson: Untouchable.

Cuoco appeared as Hannah Rinaldi in Authors Anonymous (2014), on which she also served as executive producer. Her other 2014 film credits included A Million Ways to Die in the West as Woman in the Store. In 2015, she played Gretchen Palmer in The Wedding Ringer, Katy in Burning Bodhi, and voiced Eleanor in Alvin and the Chipmunks: The Road Chip. She voiced Justine in Why Him? (2016) and appeared as herself in episodes of Comedy Bang! Bang! and Lip Sync Battle that year. She also appeared as herself in the 2017 film Handsome and the 2018 television series Best.Worst.Weekend.Ever.

In October 2017, Cuoco founded the production company Yes, Norman Productions, which entered an exclusive first-look production deal with Warner Bros. Television. In 2018, she was announced as the voice of Dr. Harleen Quinzel, also known as Harley Quinn, in the DC animated series Harley Quinn. The series premiered in 2019, with Cuoco serving as both lead voice actor and executive producer. She also voiced Pool Water in an episode of Young Sheldon in 2019. In 2020, she starred as Cassie Bowden in the HBO Max comedy-drama series The Flight Attendant, based on the novel by Chris Bohjalian, and served as executive producer. The series ran through 2022. She also appeared as Heidi in an episode of Curb Your Enthusiasm (2021).

Cuoco starred as Anne in the action comedy film The Man from Toronto (2022) and as Sheila in the romantic comedy Meet Cute (2022), serving as executive producer on the latter. From 2023 to 2024, she starred as Ava Bartlett in the television series Based on a True Story and served as executive producer. In 2023, she launched the online pet product business Oh Norman!. In 2024, she played Emma in the film Role Play, on which she also served as producer. That year, she reprised her role as Harley Quinn in an episode of the animated series Kite Man: Hell Yeah!, also serving as executive producer.

In 2026, Cuoco starred as Alice Monroe in the television series Vanished, on which she also served as executive producer. She appeared as Gloria (Widow) in an episode of Life, Larry and the Pursuit of Unhappiness (2026) and reprised her role as Penny in two episodes of Stuart Fails to Save the Universe (2026).