Isaac Powell

While in college, Powell began accumulating professional acting credits, playing Nikos in the musical Legally Blonde at the Barn Dinner Theatres. After graduating, he appeared in Newsies and Mamma Mia! with the Pittsburgh Civic Light Opera in 2017 and originated the title role in Nikola Tesla Drops the Beat at the Adirondack Theatre Festival in Glens Falls, New York, also in 2017.

Powell made his Broadway debut as Daniel in the 2017 Broadway revival of Once on This Island, which began previews in November 2017 and officially opened in December 2017. He also recorded the role for the revival's cast album.

In 2018, Powell competed on the live Broadway game show I Only Have Lies for You. That year, he also began working as a model after signing with New Pandemics modeling agency. He modeled for Palomo Spain's and NIHL's fall 2019 collections at New York Fashion Week and was featured in the final issue of Hello Mr.

Powell played Tony in the 2020 Broadway revival of West Side Story. The production began previews in December 2019 and officially opened at the Broadway Theatre on February 20, 2020, before closing early on March 11, 2020. In 2020, he was also cast as Rhys, a high school jock, in the film adaptation of Dear Evan Hansen.

In 2021, Powell was featured in the PBS concert for Wicked, which aired on August 29, 2021. In 2024, he starred as Jay Gatsby in the world premiere of Florence Welch's Gatsby: An American Myth at the American Repertory Theatre.

Powell appeared in The Moment (2026) and made aguest appearance in the second season of Adults (2026).