Katy Mixon

Mixon's first acting job came in 2001, playing Calpurnia in the Utah Shakespearean Festival's presentation of Shakespeare's Julius Caesar. Mixon moved to Los Angeles in 2003. In 2005, she starred in the premiere of the interactive theater play American Standard at the Los Angeles Edgefest. Mixon has performed at Upright Cabaret.

Mixon made her motion picture debut in the 2005 thriller film The Quiet starring Elisha Cuthbert, playing the character Michelle Fell. The next year she appeared in the romantic comedy Blind Dating playing a secondary role. Mixon had a bigger role in the 2008 comedy film Four Christmases playing Jon Favreau's younger wife. In 2009, she had roles in three films: crime drama The Informers, political thriller State of Play, and a Razzie-winning comedy All About Steve. Also from 2009 until 2013 she starred as April Buchanon in the HBO baseball comedy series Eastbound & Down opposite Danny McBride.

In 2010, Mixon was cast as Victoria Flynn in the CBS comedy series Mike & Molly opposite Melissa McCarthy and Swoosie Kurtz. During her time on Mike & Molly, Mixon co-starred alongside Jessica Chastain and Michael Shannon in the critically acclaimed independent drama film Take Shelter which was released in 2011. She had a role in the action film Drive Angry (2011) which starred Nicolas Cage; she voiced Tina Nelson in Minions (2015) as well. In 2016, she appeared alongside Jeff Bridges and Chris Pine in the critically acclaimed crime film Hell or High Water.

In 2016, Mixon was cast in the first leading role of her career on the ABC comedy series American Housewife created by Sarah Dunn. She was included in People's “One to Watch” list. The series was cancelled in 2021 after 103 episodes. In 2022, Mixon played Betsy Faria in the NBC miniseries The Thing About Pam detailing the involvement of Pam Hupp in the 2011 murder of Betsy Faria. Later that year, she was cast opposite Jessica Chastain in the Showtime musical drama miniseries George & Tammy.