Joe Locke

Locke participated in the 2020 National Theatre Connections, productions at the Gaiety Theatre, and with the Kensington Art Centre's youth group.

In 2022, Locke began starring as Charlie Spring in his debut television role in the Netflix coming-of-age series Heartstopper, an adaptation of the webcomic and graphic novel of the same name by Alice Oseman. He was chosen out of 10,000 other potential actors who were up for the role through an open casting call. Locke, who was 17 at the time of the filming, played a 15–16-year-old pupil in an English boys' grammar school.

In 2024, Locke starred in Marvel Studios' WandaVision spin-off television series Agatha All Along for Disney+. He played a goth character initially referred to as "Teen", who is later revealed to be William Kaplan. In the same year, Locke took on the role of Tobias Ragg in the musical Sweeney Todd: The Demon Barber of Fleet Street on Broadway.

In April 2025, it was announced that Locke would star in a feature length film, Heartstopper Forever, which will serve as the series finale of Heartstopper. He will also serve as an executive producer of the film. In July, it was announced that Locke would make his London West End debut in the fall, in the U.K. premiere of Clarkston, a play by Samuel D. Hunter. He debuted in the role on 17 September 2025 as "Jake".

In January 2026, it was announced that Locke would join Andrew Scott and Olivia Colman in Ian Charleson's upcoming film Elsinore.