O'Connell began her career at Stage One, an experimental theatre at the Boston Center for the Arts. She made her Broadway debut in the 1986 revival of The Front Page, and was nominated for the 1991 Drama Desk Award for Outstanding Featured Actress in a Play for her performance in the off-Broadway production Love and Anger. She is the recipient of two Drama-Logue Awards and a Los Angeles Drama Critics Circle Award for her stage work in Los Angeles.
O'Connell made her screen debut in Tin Men. Additional film credits include State of Grace, Straight Talk, Leaving Normal, Fearless, City of Angels, Hearts in Atlantis, Imaginary Heroes, Eternal Sunshine of the Spotless Mind, Wendy and Lucy, What Happens in Vegas, Secondhand Lions, and Synecdoche, New York.
She was a regular on L.A. Doctors and has made numerous guest appearances on series such as Kate & Allie, Chicago Hope, The Practice, Six Feet Under, Law & Order: Criminal Intent, and Nurse Jackie. From 1994 to 2010, O'Connell appeared on six episodes of Law & Order, four of them as Dr. Valerie Knight, Anita Van Buren's oncologist in Season 20. In 2024, she portrayed Francis Cobb in the HBO series The Penguin.
Deirdre O'Connell, Dana H
Deirdre O'Connell, Dana H.
Deirdre O'Connell, Dana H
Deirdre O'Connell, Dana H
Deirdre O'Connell, Dana H.
Deirdre O'Connell, Dana H.
Deirdre O'Connell, Fulfillment Center
Deirdre O'Connell, Fulfillment Center
Deirdre O'Connell, By the Water
Deirdre O'Connell, In the Wake
Deirdre O'Connell, Love and Anger
Deirdre O'Connell has appeared on Broadway in 2 shows.
Deirdre O'Connell has not appeared in the West End.
Distinguished Performance Awards (Drama League Awards) for Dana H, Best Performance by an Actress in a Leading Role in a Play (Tony Awards) for Dana H., Outstanding Solo Performance (Drama Desk Awards) for Dana H, Distinguished Performance Award (Drama League Awards) for Dana H, Performance Award (Obie Awards) for Dana H., Outstanding Solo Performance (Outer Critics Circle Awards) for Dana H., Outstanding Featured Actress in a Play (Drama Desk Awards) for Fulfillment Center, Distinguished Performance Award (Drama League Awards) for Fulfillment Center, Outstanding Featured Actress in a Play (The Lortels) for By the Water, Outstanding Featured Actress (The Lortels) for In the Wake and Outstanding Featured Actress - Play (Drama Desk Awards) for Love and Anger.
Deirdre O'Connell has won the Tony Award for Best Performance by an Actress in a Leading Role in a Play for Dana H. She also received the Obie Award Performance Award for Dana H., as well as the Outstanding Solo Performance award from the Outer Critics Circle Awards for her work in Dana H.
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