There are architectural pillars that will obstruct some of the major extreme side staging. If there are seats available, the ushers will attempt to move you at curtain, however don’t count on this because the show is consistently sold out.
"Sticks and stones, sister. Here, have a Valium." - Patti LuPone, a Memoir
I had one of those seats -- last row, all the way to audience right. The pillar blocked some upstage action, but for $30 it wasn't a deal-killer for me. I was able to slide one seat to my left for Act I, since that person didn't show up, and then one more seat to my left when someone left at intermission. Still somewhat obstructed, but not bad. Warning, though: It's chilly in that part of the theatre. It was a cold day, and there was quite a draft coming down from the ceiling. I wore my hat and gloves throughout the show.
I did see ushers move an elderly couple to a pair of much better seats, so you could get lucky, too.
I am generally not especially picky about seats and partial view stuff but imo the partial view seats in the Anspacher are particularly bad. I wouldn't pay any amount of money to sit in them.