In the role of a brittle biophysicist, terrified, angered and ultimately humbled by her own illness, Metcalf has found a vehicle that allows her tremendous gifts to blaze fiercely...Joe Mantello's super-sleek production perfectly mirrors the complexities of Juliana's psychological state. The set, by Eugene Lee and Edward Pierce, is a stark tangle of what could be picture frames or windows. At times illuminated in patches, at others bathed in a soft glow or deep shadow, the enclosure provides a fractured view of everything and nothing. The central character's volatile moods are echoed in the meticulous shifts of Justin Townsend's lighting and Fitz Patton's music and sound. There's a precision to the staging that enhances the puzzle-like intrigue of White's play and safeguards it from slipping into the disease-of-the-week telefilm territory it could easily inhabit.