About Fresno is a comedy about co-dependent sisters who work as hotel maids in Fresno, CA. Shannon is fresh out of sex rehab when her younger, overly optimistic lesbian sister Martha lands her a job as a maid at Fresno Suites, the local hotel. When Shannon jeopardizes her fresh start by accidentally killing a hotel guest after a post-rehab relapse, Martha goes to great lengths to help her sister cover up the crime. Shannon finally learns to take responsibility for her actions, and the sisters begin to resolve their tortured relationship.