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Describing itself as a traditional late-night talk show, Conan draws its comedy from recent news stories, political figures and prominent celebrities, as well as aspects of the show itself. The show typically opens with a monologue from Conan O'Brien relating to recent headlines and frequently features exchanges with his sidekick, Andy Richter, and members of the audience.
The next segment is devoted to a celebrity interview, with guests ranging from actors and musicians to media personalities and political figures. The show then closes with either a musical or comedy performance.