7 actors have played Irene O'Dare in Irene.
| Performer | Production | Opened |
|---|---|---|
| Edith Day | Broadway Irene | 1919 |
| Irene Dunne | Broadway Irene | 1919 |
| Dale Winter | Broadway Irene | 1923 |
| Debbie Reynolds | Broadway Irene | 1973 |
| Jane Powell | Broadway Irene | 1973 |
| Janie Sell | Broadway Irene | 1973 |
| Pamela Peadon | Broadway Irene | 1973 |
Other Roles in Irene
| Role | Production | Opened |
|---|---|---|
| Clarkson | Broadway Irene | 1919 |
| Debutante | Broadway Irene | 1919 |
| Donald Marshall | Broadway Irene | 1919 |
| Eleanor Worth | Broadway Irene | 1919 |
| Ensemble | Broadway Irene | 1919 |
| Helen Cheston | Broadway Irene | 1919 |
| Irene O'Dare | Broadway Irene | 1919 |
| J.P. Bowden | Broadway Irene | 1919 |
| Jane Gilmour | Broadway Irene | 1919 |
| Lawrence Hadley | Broadway Irene | 1919 |
| Madame Lucy | Broadway Irene | 1919 |
| Mrs. Cheston | Broadway Irene | 1919 |
| Mrs. Marshall | Broadway Irene | 1919 |
| Mrs. O'Dare | Broadway Irene | 1919 |
| Performer | Broadway Irene | 1919 |
| Robert Harrison | Broadway Irene | 1919 |
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