Mnemonic has won several awards, including Outstanding Lighting Design (Drama Desk Awards) for Paul Anderson, Outstanding Sound Design (Drama Desk Awards) for Christopher Shutt, and Unique Theatrical Experience (Drama Desk Awards) for Mnemonic. The show also received recognition at The Lortels, with awards for Outstanding Director for Simon McBurney, Outstanding Lighting Design for Paul Anderson, and Outstanding Sound Design for Christopher Shutt. Additionally, Mnemonic won the Unique Theatrical Experience award at The Lortels for Richard Frankel, Dede Harris, Lorie Cowen Levy, Timothy Childs, Herb Goldsmith, Libby Adler Mages, Mari Glich, Margo Lion, Marc Routh, Steven Baruch, and Thomas Viertel.