I really want to suggest "Rabbit Hole" by David Lindsay-Abaire, but that's 3w, 1m, and a boy. Maybe if one of the women can play a kid? I read the script and the gender of the kid doesn't seem important from what I can recall
If not, and you can get more women actors, "Jake's Women" by Neil Simon would be nice. That's 7w and 1m
C.Jack said: "Help! I need help finding a play for my college class that has a cast comprised of Four females and One male!"
You can search by these parameters on Dramatists and Sam French. Some results:
Be Aggressive by Annie Weisman Crumbs from the Table of Joy by Lynn Nottage The Exact Center of the Universe by Joan Vail Thorne Fix Me, Jesus by Helen Sneed The Glamour House by Lydia Stryk Going to See the Elephant by Karen Hensel & Elana Kant Heartless by Sam Shepard Leaves by Lucy Caldwell Mine by Laura Marks Miss Witherspoon by Christopher Durang Rapture, Blister, Burn by Gina Gionfriddo When We Were Young and Unafraid by Sarah Treem The Clean House by Sarah Ruhl The Cemetery Club by Ivan Menchell The Trials and Tribulations of a Trailer Trash Housewife by Del Shores & Joe Patrick Ward