Study Shows First Practical Intervention For Chemobrain
Researchers reported that the intervention group, as compared to the control group, reported significantly better Perceived Cognitive Impairment (the primary outcome measure: FACT-COG PCI) immediately after the intervention (p<0.0001), and six months later (p<0.0002).
The intervention group also had significantly better performance on many secondary measures, including: on the stress measure after intervention and at six months; fatigue and anxiety/depression measures after training and with a trend to better performance at six months; on the quality of life measure at six months, but not immediately after training; and on all FACT-COG subscales after intervention, but only on some at six months. The computerized neuropsychological assessment (Cogstate) showed no between group difference after training or six months later.
The use of this web-based intervention led to improvements in cognitive symptoms that were sustained six months later, said Dr. Janette Vardy of the University of Sydney, the senior author on the paper. While this builds on prior work, to our knowledge, it is the largest trial showing improvement in cognitive symptoms among cancer survivors after chemotherapy.
This is an important step forward, commented Dr. Diane Von Ah of Indiana University, who ran a prior study using the same intervention, with similar results, in a classroom setting. This new study suggests that this program can be used successfully in the home to address a serious problem that has too often been ignored, trivialized, or even denied to exist.
We are excited by the addition of these independent research results to our body of knowledge, said Dr. Henry Mahncke, CEO of Posit Science, the maker of the BrainHQ exercises used in this intervention. We plan to approach appropriate regulatory agencies to explore the shortest path to getting a form of these exercises into the hands of patients who may be helped.
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